The objective of this study was to evaluate the pathways to enhance resilience to increased climate variability and directional change among pastoral households in Simanjiro District in Northern Tanzania. The study used household survey and rainfall and temperature data. Results indicate increasing temperature and decreasing precipitation trends over the past four decades. Also, extreme climatic events, particularly drought, have become more frequent. Food and water insecurity are key factors causing an increased household vulnerability. Increased climate change-induced malaria prevalence poses additional health risks. Household adaptive strategies include livelihood diversification and migration. Local institutions are instrumental in enhancing climate change resilience at the local level. We conclude that livelihood diversification and migration are key pathways to enhancing households’ climate change resilience.