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Patient profiling for success after weight loss surgery (GO Bypass study): an interdisciplinary study protocol

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Patient profiling for success after weight loss surgery (GO Bypass study) : an interdisciplinary study protocol. / Christensen, Bodil Just; Schmidt, Julie Berg; Nielsen, Mette Søndergaard; Tækker, Louise; Holm, Lotte; Lunn, Susanne; Bredie, Wender; Ritz, Christian; Holst, Jens Juul; Hansen, Torben; Hilbert, Anja; le Roux, Carel W.; Hulme, Oliver J.; Siebner, Hartwig Roman; Morville, Tobias; Naver, Lars; Floyd, Andrea Karen; Sjödin, Anders Mikael.

In: Contemporary Clinical Trials Communications, Vol. 10, 2018, p. 121-130.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Christensen, BJ, Schmidt, JB, Nielsen, MS, Tækker, L, Holm, L, Lunn, S, Bredie, W, Ritz, C, Holst, JJ, Hansen, T, Hilbert, A, le Roux, CW, Hulme, OJ, Siebner, HR, Morville, T, Naver, L, Floyd, AK & Sjödin, AM 2018, 'Patient profiling for success after weight loss surgery (GO Bypass study): an interdisciplinary study protocol' Contemporary Clinical Trials Communications, vol. 10, pp. 121-130. https://doi.org/10.1016/j.conctc.2018.02.002

APA

Christensen, B. J., Schmidt, J. B., Nielsen, M. S., Tækker, L., Holm, L., Lunn, S., ... Sjödin, A. M. (2018). Patient profiling for success after weight loss surgery (GO Bypass study): an interdisciplinary study protocol. Contemporary Clinical Trials Communications, 10, 121-130. https://doi.org/10.1016/j.conctc.2018.02.002

Vancouver

Christensen BJ, Schmidt JB, Nielsen MS, Tækker L, Holm L, Lunn S et al. Patient profiling for success after weight loss surgery (GO Bypass study): an interdisciplinary study protocol. Contemporary Clinical Trials Communications. 2018;10:121-130. https://doi.org/10.1016/j.conctc.2018.02.002

Author

Christensen, Bodil Just ; Schmidt, Julie Berg ; Nielsen, Mette Søndergaard ; Tækker, Louise ; Holm, Lotte ; Lunn, Susanne ; Bredie, Wender ; Ritz, Christian ; Holst, Jens Juul ; Hansen, Torben ; Hilbert, Anja ; le Roux, Carel W. ; Hulme, Oliver J. ; Siebner, Hartwig Roman ; Morville, Tobias ; Naver, Lars ; Floyd, Andrea Karen ; Sjödin, Anders Mikael. / Patient profiling for success after weight loss surgery (GO Bypass study) : an interdisciplinary study protocol. In: Contemporary Clinical Trials Communications. 2018 ; Vol. 10. pp. 121-130.

Bibtex

@article{b412a9986e744d7f9c1a71eb3da8f371,
title = "Patient profiling for success after weight loss surgery (GO Bypass study): an interdisciplinary study protocol",
abstract = "Despite substantial research efforts, the mechanisms proposed to explain weight loss after gastric bypass (RYGB) and sleeve gastrectomy (SL) do not explain the large individual variation seen after these treatments. A complex set of factors are involved in the onset and development of obesity and these may also be relevant for the understanding of why success with treatments vary considerably between individuals. This calls for explanatory models that take into account not only biological determinants but also behavioral, affective and contextual factors. In this prospective study, we recruited 47 women and 8 men, aged 25–56 years old, with a BMI of 45.8 ± 7.1 kg/m2 from the waiting list for RYGB and SL at K{\o}ge hospital, Denmark. Pre-surgery and 1.5, 6 and 18 months after surgery we assessed various endpoints spanning multiple domains. Endpoints were selected on basis of previous studies and include: physiological measures: anthropometrics, vital signs, biochemical measures and appetite hormones, genetics, gut microbiota, appetite sensation, food and taste preferences, neural sensitivity, sensory perception and movement behaviors; psychological measures: general psychiatric symptom-load, depression, eating disorders, ADHD, personality disorder, impulsivity, emotion regulation, attachment pattern, general self-efficacy, alexithymia, internalization of weight bias, addiction, quality of life and trauma; and sociological and anthropological measures: sociodemographic measures, eating behavior, weight control practices and psycho-social factors.Joining these many endpoints and methodologies from different scientific disciplines and creating a multi-dimensional predictive model has not previously been attempted. Data on the primary endpoint are expected to be published in 2018.",
author = "Christensen, {Bodil Just} and Schmidt, {Julie Berg} and Nielsen, {Mette S{\o}ndergaard} and Louise T{\ae}kker and Lotte Holm and Susanne Lunn and Wender Bredie and Christian Ritz and Holst, {Jens Juul} and Torben Hansen and Anja Hilbert and {le Roux}, {Carel W.} and Hulme, {Oliver J.} and Siebner, {Hartwig Roman} and Tobias Morville and Lars Naver and Floyd, {Andrea Karen} and Sj{\"o}din, {Anders Mikael}",
note = "CURIS 2018 NEXS 135",
year = "2018",
doi = "10.1016/j.conctc.2018.02.002",
language = "English",
volume = "10",
pages = "121--130",
journal = "Contemporary Clinical Trials Communications",
issn = "2451-8654",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Patient profiling for success after weight loss surgery (GO Bypass study)

T2 - an interdisciplinary study protocol

AU - Christensen, Bodil Just

AU - Schmidt, Julie Berg

AU - Nielsen, Mette Søndergaard

AU - Tækker, Louise

AU - Holm, Lotte

AU - Lunn, Susanne

AU - Bredie, Wender

AU - Ritz, Christian

AU - Holst, Jens Juul

AU - Hansen, Torben

AU - Hilbert, Anja

AU - le Roux, Carel W.

AU - Hulme, Oliver J.

AU - Siebner, Hartwig Roman

AU - Morville, Tobias

AU - Naver, Lars

AU - Floyd, Andrea Karen

AU - Sjödin, Anders Mikael

N1 - CURIS 2018 NEXS 135

PY - 2018

Y1 - 2018

N2 - Despite substantial research efforts, the mechanisms proposed to explain weight loss after gastric bypass (RYGB) and sleeve gastrectomy (SL) do not explain the large individual variation seen after these treatments. A complex set of factors are involved in the onset and development of obesity and these may also be relevant for the understanding of why success with treatments vary considerably between individuals. This calls for explanatory models that take into account not only biological determinants but also behavioral, affective and contextual factors. In this prospective study, we recruited 47 women and 8 men, aged 25–56 years old, with a BMI of 45.8 ± 7.1 kg/m2 from the waiting list for RYGB and SL at Køge hospital, Denmark. Pre-surgery and 1.5, 6 and 18 months after surgery we assessed various endpoints spanning multiple domains. Endpoints were selected on basis of previous studies and include: physiological measures: anthropometrics, vital signs, biochemical measures and appetite hormones, genetics, gut microbiota, appetite sensation, food and taste preferences, neural sensitivity, sensory perception and movement behaviors; psychological measures: general psychiatric symptom-load, depression, eating disorders, ADHD, personality disorder, impulsivity, emotion regulation, attachment pattern, general self-efficacy, alexithymia, internalization of weight bias, addiction, quality of life and trauma; and sociological and anthropological measures: sociodemographic measures, eating behavior, weight control practices and psycho-social factors.Joining these many endpoints and methodologies from different scientific disciplines and creating a multi-dimensional predictive model has not previously been attempted. Data on the primary endpoint are expected to be published in 2018.

AB - Despite substantial research efforts, the mechanisms proposed to explain weight loss after gastric bypass (RYGB) and sleeve gastrectomy (SL) do not explain the large individual variation seen after these treatments. A complex set of factors are involved in the onset and development of obesity and these may also be relevant for the understanding of why success with treatments vary considerably between individuals. This calls for explanatory models that take into account not only biological determinants but also behavioral, affective and contextual factors. In this prospective study, we recruited 47 women and 8 men, aged 25–56 years old, with a BMI of 45.8 ± 7.1 kg/m2 from the waiting list for RYGB and SL at Køge hospital, Denmark. Pre-surgery and 1.5, 6 and 18 months after surgery we assessed various endpoints spanning multiple domains. Endpoints were selected on basis of previous studies and include: physiological measures: anthropometrics, vital signs, biochemical measures and appetite hormones, genetics, gut microbiota, appetite sensation, food and taste preferences, neural sensitivity, sensory perception and movement behaviors; psychological measures: general psychiatric symptom-load, depression, eating disorders, ADHD, personality disorder, impulsivity, emotion regulation, attachment pattern, general self-efficacy, alexithymia, internalization of weight bias, addiction, quality of life and trauma; and sociological and anthropological measures: sociodemographic measures, eating behavior, weight control practices and psycho-social factors.Joining these many endpoints and methodologies from different scientific disciplines and creating a multi-dimensional predictive model has not previously been attempted. Data on the primary endpoint are expected to be published in 2018.

U2 - 10.1016/j.conctc.2018.02.002

DO - 10.1016/j.conctc.2018.02.002

M3 - Journal article

VL - 10

SP - 121

EP - 130

JO - Contemporary Clinical Trials Communications

JF - Contemporary Clinical Trials Communications

SN - 2451-8654

ER -

ID: 192452019