Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures. / Nielsen, Mette Søndergaard; Christensen, Bodil Just; Schmidt, Julie Berg; Tækker, Louise; Holm, Lotte; Lunn, Susanne; Ritz, Christian; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens Juul; Schnurr, Theresia Maria; Hansen, Torben; le Roux, Carel W; Lund, Thomas Bøker; Floyd, Andrea Karen; Sjödin, Anders Mikael.
In: International Journal of Obesity, Vol. 44, No. 11, 2020, p. 2291-2302.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures
AU - Nielsen, Mette Søndergaard
AU - Christensen, Bodil Just
AU - Schmidt, Julie Berg
AU - Tækker, Louise
AU - Holm, Lotte
AU - Lunn, Susanne
AU - Ritz, Christian
AU - Albrechtsen, Nicolai Jacob Wewer
AU - Holst, Jens Juul
AU - Schnurr, Theresia Maria
AU - Hansen, Torben
AU - le Roux, Carel W
AU - Lund, Thomas Bøker
AU - Floyd, Andrea Karen
AU - Sjödin, Anders Mikael
N1 - CURIS 2020 NEXS 128
PY - 2020
Y1 - 2020
N2 - Background: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.Methods: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).Results: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).Conclusions: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.
AB - Background: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.Methods: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).Results: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).Conclusions: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.
U2 - 10.1038/s41366-020-0576-9
DO - 10.1038/s41366-020-0576-9
M3 - Journal article
C2 - 32327722
VL - 44
SP - 2291
EP - 2302
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 11
ER -
ID: 240794827