Hjalte List Larsen
Assistant Professor
Jensen Lab
Ole Maaløes Vej 5, 2200 København N.
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My research focuses on understanding mechanisms governing cell state transitions during intestinal development and disease. Using 3D organoid models, we characterize the emergence of intestinal stem cells during development and unravel the transcriptional and epigenetic regulators facilitating progressive maturation in the intestinal epithelium during development. We capitalize on these insights in research focusing on regeneration of the adult intestinal epithelium following injury, as we and others have demonstrated that the adult epithelium is transiently reprogrammed to a fetal-like state during repair of the wounded epithelium. We model in vivo relevant cell state transitions during injury and repair using adult intestinal organoids, and utilize these to uncover novel regulators of fetal-like reprogramming and regeneration in the adult epithelium. By combining organoid cultures with next generation sequencing, single-cell RNA-seq, CRISPR-Cas9 based gene editing, proteomics and functional assays in vitro and in vivo, we ultimately aim at developing conceptually novel treatment strategies to enhance endogenous epithelial regeneration in patients suffering from inflammatory bowel disease.
ID: 32450359
Most downloads
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384
downloads
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
Research output: Contribution to journal › Journal article › Research › peer-review
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186
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Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis
Research output: Contribution to journal › Journal article › Research › peer-review
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151
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Deconstructing the principles of ductal network formation in the pancreas
Research output: Contribution to journal › Journal article › Research › peer-review
Published