Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?
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Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia? / Hegelund, Maria Hein; Ryrsø, Camilla Koch; Ritz, Christian; Dungu, Arnold Matovu; Sejdic, Adin; Jensen, Andreas V; Hansen, Nikita Misella; Mølgaard, Christian; Krogh-Madsen, Rikke; Lindegaard, Birgitte; Faurholt-Jepsen, Daniel.
In: Nutrients, Vol. 14, No. 22, 4906, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?
AU - Hegelund, Maria Hein
AU - Ryrsø, Camilla Koch
AU - Ritz, Christian
AU - Dungu, Arnold Matovu
AU - Sejdic, Adin
AU - Jensen, Andreas V
AU - Hansen, Nikita Misella
AU - Mølgaard, Christian
AU - Krogh-Madsen, Rikke
AU - Lindegaard, Birgitte
AU - Faurholt-Jepsen, Daniel
N1 - CURIS 2022 NEXS 282
PY - 2022
Y1 - 2022
N2 - Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival.
AB - Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival.
KW - Faculty of Science
KW - Community-acquired pneumonia
KW - Undernutrition
KW - Obesity
KW - Re-hospitalization
KW - Mortality
U2 - 10.3390/nu14224906
DO - 10.3390/nu14224906
M3 - Journal article
C2 - 36432592
VL - 14
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 22
M1 - 4906
ER -
ID: 327124978