Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats
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Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats. / Niemiec, T.; Sawosz, E.; Chwalibog, André.
In: Journal of Animal and Feed Sciences, Vol. 14, No. Suppl.1, 2005, p. 553-556.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats
AU - Niemiec, T.
AU - Sawosz, E.
AU - Chwalibog, André
PY - 2005
Y1 - 2005
N2 - The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4x10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.
AB - The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4x10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.
KW - Former LIFE faculty
KW - ascorbic acid
KW - antioxidative/oxidative state
KW - rats
M3 - Journal article
VL - 14
SP - 553
EP - 556
JO - Journal of Animal and Feed Sciences
JF - Journal of Animal and Feed Sciences
SN - 1230-1388
IS - Suppl.1
ER -
ID: 8000569