The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy
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The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy. / Pang, Michelle D; Bastings, Jacco J A J; Op den Kamp-Bruls, Yvonne M H; Harrold, Joanne A; Kjølbæk, Louise; Halford, Jason C G; Adam, Tanja C M; Raben, Anne; Schrauwen-Hinderling, Vera B; Goossens, Gijs H; Blaak, Ellen E.
In: Obesity, Vol. 31, No. 7, 2023, p. 1745-1754.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy
AU - Pang, Michelle D
AU - Bastings, Jacco J A J
AU - Op den Kamp-Bruls, Yvonne M H
AU - Harrold, Joanne A
AU - Kjølbæk, Louise
AU - Halford, Jason C G
AU - Adam, Tanja C M
AU - Raben, Anne
AU - Schrauwen-Hinderling, Vera B
AU - Goossens, Gijs H
AU - Blaak, Ellen E
N1 - Publisher Copyright: © 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
PY - 2023
Y1 - 2023
N2 - Objective: This study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. Methods: In this secondary analysis of the European SWEET project, 50 adults (age 18–65 years) with overweight or obesity (BMI ≥ 25 kg/m2) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). Results: The LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). Conclusions: Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.
AB - Objective: This study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. Methods: In this secondary analysis of the European SWEET project, 50 adults (age 18–65 years) with overweight or obesity (BMI ≥ 25 kg/m2) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). Results: The LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). Conclusions: Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.
KW - Faculty of Science
KW - Weight loss
KW - Insulin sensitivity
KW - Intrahepatic lipid
KW - Overweight
KW - Obesity
U2 - 10.1002/oby.23773
DO - 10.1002/oby.23773
M3 - Journal article
C2 - 37368517
AN - SCOPUS:85163583159
VL - 31
SP - 1745
EP - 1754
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 7
ER -
ID: 361378845