Biotechnological Trends in Spider and Scorpion Antivenom Development
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Biotechnological Trends in Spider and Scorpion Antivenom Development. / Laustsen, Andreas Hougaard; Solà, Mireia; Jappe, Emma Christine; Oscoz Cob, Saioa; Lauridsen, Line; Engmark, Mikael.
In: Toxins, Vol. 8, No. 8, 226, 2016, p. 1-33.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Biotechnological Trends in Spider and Scorpion Antivenom Development
AU - Laustsen, Andreas Hougaard
AU - Solà, Mireia
AU - Jappe, Emma Christine
AU - Oscoz Cob, Saioa
AU - Lauridsen, Line
AU - Engmark, Mikael
PY - 2016
Y1 - 2016
N2 - Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving crystal structures of membrane-embedded receptors. Additionally, the identification and isolation of a myriad of spider and scorpion toxins has allowed research within next generation antivenoms to progress at an increasingly faster pace. In this review, the current knowledge of spider and scorpion venoms is presented, followed by a discussion of all published biotechnological efforts within development of spider and scorpion antitoxins based on small molecules, antibodies and fragments thereof, and next generation immunization strategies. The increasing number of discovery and development efforts within this field may point towards an upcoming transition from serum-based antivenoms towards therapeutic solutions based on modern biotechnology.
AB - Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving crystal structures of membrane-embedded receptors. Additionally, the identification and isolation of a myriad of spider and scorpion toxins has allowed research within next generation antivenoms to progress at an increasingly faster pace. In this review, the current knowledge of spider and scorpion venoms is presented, followed by a discussion of all published biotechnological efforts within development of spider and scorpion antitoxins based on small molecules, antibodies and fragments thereof, and next generation immunization strategies. The increasing number of discovery and development efforts within this field may point towards an upcoming transition from serum-based antivenoms towards therapeutic solutions based on modern biotechnology.
KW - Faculty of Health and Medical Sciences
KW - Antivenom
KW - Spider Venoms
KW - Scorpion Venoms
KW - Antibodies
KW - Venomics
KW - Antivenom Design
KW - Venom Neutralization
KW - Antitoxins
U2 - 10.3390/toxins8080226
DO - 10.3390/toxins8080226
M3 - Journal article
C2 - 27455327
VL - 8
SP - 1
EP - 33
JO - Toxins
JF - Toxins
SN - 2072-6651
IS - 8
M1 - 226
ER -
ID: 164111267