Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats
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The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4x10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Animal and Feed Sciences |
Vol/bind | 14 |
Udgave nummer | Suppl.1 |
Sider (fra-til) | 553-556 |
Antal sider | 4 |
ISSN | 1230-1388 |
Status | Udgivet - 2005 |
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ID: 8000569