The time is now: Regular exercise maintains vascular health in aging women
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The time is now: Regular exercise maintains vascular health in aging women. / Tamariz‐Ellemann, Andrea; Wickham, Kate Aiko; Nørregaard, Line Boel; Gliemann, Lasse; Hellsten, Ylva.
I: Journal of Physiology, Bind 601, Nr. 11, 2023, s. 2085-2098.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The time is now: Regular exercise maintains vascular health in aging women
AU - Tamariz‐Ellemann, Andrea
AU - Wickham, Kate Aiko
AU - Nørregaard, Line Boel
AU - Gliemann, Lasse
AU - Hellsten, Ylva
N1 - CURIS 2023 NEXS 149
PY - 2023
Y1 - 2023
N2 - Although aging impairs cardiovascular health in both men and women, the timeline is different between the sexes. This is at least partially attributed to the loss of estrogen in women at midlife, in connection with menopause. Estrogen has protective effects on the cardiovascular system, and menopause consequently leads to a rapid and significant decline in cardiovascular health. Notably, estrogen interacts with its nuclear and membrane receptors leading to changes in proteins of importance for cardiovascular health. Skeletal muscle activity, which affects the expression of many of the same proteins as estrogen, could potentially counteract the loss of estrogen at menopause. The hypothesis that exercise can counteract the loss of estrogen has been explored in several recent studies. It has been found that regular physical activity opposes the detrimental effects not only of aging, but also the menopausal transition, on cardiovascular health. Although, vascular benefits can be gained at all ages, initiating physical activity at or soon after menopause may be more effective than at a later time point in life. Intuitively, it is easier to prevent decrements than attempting to regain lost vascular health. This idea is supported by evidence at the molecular level, suggesting that exercise-induced activation of the estrogen-related receptor-α pathway is more effective soon after menopause compared to later. Together, although a decline in cardiovascular health due to chronological aging cannot be completely prevented, a physically active lifestyle mitigates age-related cardiovascular impairments. Importantly, regular physical activity through life should always be addressed as the biological norm.
AB - Although aging impairs cardiovascular health in both men and women, the timeline is different between the sexes. This is at least partially attributed to the loss of estrogen in women at midlife, in connection with menopause. Estrogen has protective effects on the cardiovascular system, and menopause consequently leads to a rapid and significant decline in cardiovascular health. Notably, estrogen interacts with its nuclear and membrane receptors leading to changes in proteins of importance for cardiovascular health. Skeletal muscle activity, which affects the expression of many of the same proteins as estrogen, could potentially counteract the loss of estrogen at menopause. The hypothesis that exercise can counteract the loss of estrogen has been explored in several recent studies. It has been found that regular physical activity opposes the detrimental effects not only of aging, but also the menopausal transition, on cardiovascular health. Although, vascular benefits can be gained at all ages, initiating physical activity at or soon after menopause may be more effective than at a later time point in life. Intuitively, it is easier to prevent decrements than attempting to regain lost vascular health. This idea is supported by evidence at the molecular level, suggesting that exercise-induced activation of the estrogen-related receptor-α pathway is more effective soon after menopause compared to later. Together, although a decline in cardiovascular health due to chronological aging cannot be completely prevented, a physically active lifestyle mitigates age-related cardiovascular impairments. Importantly, regular physical activity through life should always be addressed as the biological norm.
KW - Faculty of Science
KW - Aging
KW - Exercise
KW - Menopause
KW - Vascular Health
U2 - 10.1113/JP282896
DO - 10.1113/JP282896
M3 - Review
C2 - 36300822
VL - 601
SP - 2085
EP - 2098
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 11
ER -
ID: 323839797