The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo
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The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo. / Verhagen, H.; Aruoma, O.I.; van Delft, J.H.M.; Dragsted, Lars Ove; Ferguson, L.R.; Knasmüller, S.; Pool-Zobel, B.L.; Poulsen, H.E.; Williamson, G.; Yannai, S.
I: Food and Chemical Toxicology, Bind 41, Nr. 5, 2003, s. 603-610.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo
AU - Verhagen, H.
AU - Aruoma, O.I.
AU - van Delft, J.H.M.
AU - Dragsted, Lars Ove
AU - Ferguson, L.R.
AU - Knasmüller, S.
AU - Pool-Zobel, B.L.
AU - Poulsen, H.E.
AU - Williamson, G.
AU - Yannai, S.
N1 - (Ekstern)
PY - 2003
Y1 - 2003
N2 - There is increasing evidence that chemicals/test substances cannot only have adverse effects, but that there are many substances that can (also) have a beneficial effect on health. As this journal regularly publishes papers in this area and has every intention in continuing to do so in the near future, it has become essential that studies reported in this journal reflect an adequate level of scientific scrutiny. Therefore a set of essential characteristics of studies has been defined. These basic requirements are default properties rather than non-negotiables: deviations are possible and useful, provided they can be justified on scientific grounds. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo concern the following areas: (1) Hypothesis-driven study design; (2) The nature of the test substance; (3) Valid and invalid test systems; (4) The selection of dose levels and gender; (5) Reversal of the effects induced by oxidants, carcinogens and mutagens; (6) Route of administration; (7) Number and validity of test variables; (8) Repeatability and reproducibility; (9) Statistics; and (10) Quality Assurance.
AB - There is increasing evidence that chemicals/test substances cannot only have adverse effects, but that there are many substances that can (also) have a beneficial effect on health. As this journal regularly publishes papers in this area and has every intention in continuing to do so in the near future, it has become essential that studies reported in this journal reflect an adequate level of scientific scrutiny. Therefore a set of essential characteristics of studies has been defined. These basic requirements are default properties rather than non-negotiables: deviations are possible and useful, provided they can be justified on scientific grounds. The 10 basic requirements for a scientific paper reporting antioxidant, antimutagenic or anticarcinogenic potential of test substances in in vitro experiments and animal studies in vivo concern the following areas: (1) Hypothesis-driven study design; (2) The nature of the test substance; (3) Valid and invalid test systems; (4) The selection of dose levels and gender; (5) Reversal of the effects induced by oxidants, carcinogens and mutagens; (6) Route of administration; (7) Number and validity of test variables; (8) Repeatability and reproducibility; (9) Statistics; and (10) Quality Assurance.
KW - Faculty of Science
KW - Requirements
KW - Antioxidant
KW - Antimutagenic
KW - Anticarcinogenic
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0037401333&partnerID=MN8TOARS
U2 - 10.1016/S0278-6915(03)00025-5
DO - 10.1016/S0278-6915(03)00025-5
M3 - Journal article
VL - 41
SP - 603
EP - 610
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
IS - 5
ER -
ID: 273754284