Long-term exposure to air pollution and road traffic noise and incidence of dementia in the Danish Nurse Cohort
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Long-term exposure to air pollution and road traffic noise and incidence of dementia in the Danish Nurse Cohort. / Tuffier, Stéphane; Zhang, Jiawei; Bergmann, Marie; So, Rina; Napolitano, George Maria; Cole-Hunter, Thomas; Maric, Matija; Antic, Sonja; Brandt, Jørgen; Ketzel, Matthias; Loft, Steffen; Lim, Youn-Hee; Andersen, Zorana Jovanovic.
I: Alzheimer's & Dementia, Bind 20, Nr. 6, 2024, s. 4080-4091.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Long-term exposure to air pollution and road traffic noise and incidence of dementia in the Danish Nurse Cohort
AU - Tuffier, Stéphane
AU - Zhang, Jiawei
AU - Bergmann, Marie
AU - So, Rina
AU - Napolitano, George Maria
AU - Cole-Hunter, Thomas
AU - Maric, Matija
AU - Antic, Sonja
AU - Brandt, Jørgen
AU - Ketzel, Matthias
AU - Loft, Steffen
AU - Lim, Youn-Hee
AU - Andersen, Zorana Jovanovic
N1 - © 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024
Y1 - 2024
N2 - INTRODUCTION: We examined the association of long-term exposure to air pollution and road traffic noise with dementia incidence in the Danish Nurse Cohort.METHODS: Female nurses were followed for dementia incidence (hospital contact or medication prescription) from 1993/1999 to 2020. Air pollution and road traffic noise levels were estimated at nurses' residences, and their associations with dementia were examined using Cox regression models.RESULTS: Of 25,233 nurses 1409 developed dementia. Particulate matter with a diameter of ≤2.5 µm (PM 2.5) was associated with dementia incidence, after adjusting for lifestyle, socioeconomic status, and road traffic noise (hazard ratio [95% confidence interval] 1.35 [1.15-1.59] per interquartile range of 2.6 µg/m 3). There was no association of PM2.5 with dementia in physically active nurses. Association with road traffic noise diminished after adjusting for PM₂.₅ (1.02 [0.93-1.11] per 7.6 dB). DISCUSSION: Long-term exposure to air pollution increases risk of dementia, and physical activity may moderate this risk.HIGHLIGHTS: Long-term exposure to air pollution was associated with increased risk of dementia among female nurses from the Danish Nurse Cohort. Association of air pollution with dementia was independent of road traffic noise. Association of road traffic noise with dementia diminished after adjusting for air pollution. Physical activity moderated adverse effects of air pollution on dementia.
AB - INTRODUCTION: We examined the association of long-term exposure to air pollution and road traffic noise with dementia incidence in the Danish Nurse Cohort.METHODS: Female nurses were followed for dementia incidence (hospital contact or medication prescription) from 1993/1999 to 2020. Air pollution and road traffic noise levels were estimated at nurses' residences, and their associations with dementia were examined using Cox regression models.RESULTS: Of 25,233 nurses 1409 developed dementia. Particulate matter with a diameter of ≤2.5 µm (PM 2.5) was associated with dementia incidence, after adjusting for lifestyle, socioeconomic status, and road traffic noise (hazard ratio [95% confidence interval] 1.35 [1.15-1.59] per interquartile range of 2.6 µg/m 3). There was no association of PM2.5 with dementia in physically active nurses. Association with road traffic noise diminished after adjusting for PM₂.₅ (1.02 [0.93-1.11] per 7.6 dB). DISCUSSION: Long-term exposure to air pollution increases risk of dementia, and physical activity may moderate this risk.HIGHLIGHTS: Long-term exposure to air pollution was associated with increased risk of dementia among female nurses from the Danish Nurse Cohort. Association of air pollution with dementia was independent of road traffic noise. Association of road traffic noise with dementia diminished after adjusting for air pollution. Physical activity moderated adverse effects of air pollution on dementia.
KW - Faculty of Health and Medical Sciences
KW - air pollution
KW - cohort studies
KW - dementia
KW - Europe
KW - incidence
KW - noise transportation
KW - nurses
KW - physical activity
KW - women
U2 - 10.1002/alz.13814
DO - 10.1002/alz.13814
M3 - Journal article
C2 - 38716818
VL - 20
SP - 4080
EP - 4091
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
SN - 1552-5260
IS - 6
ER -
ID: 391264970