Antifungal metabolites from fungal endophytes of Pinus strobus
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Antifungal metabolites from fungal endophytes of Pinus strobus. / Sumarah, Mark W; Kesting, Julie R; Sørensen, Dan; Miller, J David.
In: Phytochemistry, Vol. 72, No. 14-15, 01.10.2011, p. 1833-1837.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antifungal metabolites from fungal endophytes of Pinus strobus
AU - Sumarah, Mark W
AU - Kesting, Julie R
AU - Sørensen, Dan
AU - Miller, J David
N1 - Keywords: Eastern white pine; Pinus strobus; Pinaceae; Cronartium ribicola; Microbotryum violaceum; Endophyte; LC-MS-SPE/NMR
PY - 2011/10/1
Y1 - 2011/10/1
N2 - The extracts of five foliar fungal endophytes isolated from Pinus strobus (eastern white pine) that showed antifungal activity in disc diffusion assays were selected for further study. From these strains, the aliphatic polyketide compound 1 and three related sesquiterpenes 2-4 were isolated and characterized. Compound 2 is reported for the first time as a natural product and the E/Z conformational isomers 3 and 4 were hitherto unknown. Additionally, the three known macrolides; pyrenophorol (5), dihydropyrenophorin (6), and pyrenophorin (7) were isolated and identified. Their structures were elucidated by spectroscopic analyses including 2D NMR, HRMS and by comparison to literature data where available. The isolated compounds 1, 2, and 5 were antifungal against both the rust Microbotryum violaceum and Saccharomyces cerevisae.
AB - The extracts of five foliar fungal endophytes isolated from Pinus strobus (eastern white pine) that showed antifungal activity in disc diffusion assays were selected for further study. From these strains, the aliphatic polyketide compound 1 and three related sesquiterpenes 2-4 were isolated and characterized. Compound 2 is reported for the first time as a natural product and the E/Z conformational isomers 3 and 4 were hitherto unknown. Additionally, the three known macrolides; pyrenophorol (5), dihydropyrenophorin (6), and pyrenophorin (7) were isolated and identified. Their structures were elucidated by spectroscopic analyses including 2D NMR, HRMS and by comparison to literature data where available. The isolated compounds 1, 2, and 5 were antifungal against both the rust Microbotryum violaceum and Saccharomyces cerevisae.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1016/j.phytochem.2011.05.003
DO - 10.1016/j.phytochem.2011.05.003
M3 - Journal article
C2 - 21632082
VL - 72
SP - 1833
EP - 1837
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
IS - 14-15
ER -
ID: 35410668