Calibration of bioelectrical impedance analysis against deuterium dilution for body composition assessment in stunted Ugandan children
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Calibration of bioelectrical impedance analysis against deuterium dilution for body composition assessment in stunted Ugandan children. / Lewis, Jack Ivor; Friis, Henrik; Mupere, Ezekiel; Wells, Jonathan C; Grenov, Benedikte.
In: Journal of Nutrition, Vol. 153, No. 2, 2023, p. 426-434.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Calibration of bioelectrical impedance analysis against deuterium dilution for body composition assessment in stunted Ugandan children
AU - Lewis, Jack Ivor
AU - Friis, Henrik
AU - Mupere, Ezekiel
AU - Wells, Jonathan C
AU - Grenov, Benedikte
N1 - CURIS 2023 NEXS 024
PY - 2023
Y1 - 2023
N2 - Background: BIA represents an important tool in body composition (BC) assessment, especially in low-income settings in which simple and affordable options are preferred. There is a particular need to measure BC in stunted children, in which cases population-specific BIA estimating equations are lacking.Objective: We calibrated an equation to estimate body composition from BIA using deuterium dilution (2H) as the criterion method in stunted children.Methods: We measured BC with 2H and performed BIA in stunted Ugandan children (n = 50). Multiple linear regression models were constructed to predict 2H-derived FFM from BIA-derived whole-body impedance and other relevant predictors. Model performance was expressed as adjusted R2 and RMSE. Prediction errors were also calculated.Results: Participants were aged 16-59 mo, at whom 46% were girls, and their median [IQR] height-for-age z-score (HAZ) was -2.58 [-2.92, -2.37] according to WHO growth standards. Impedance index (height2/impendance measured at 50 kHz) alone explained 89.2% variation in FFM and had an RMSE of 583 g (precision error 6.5%). The final model contained age, sex, impedance index and height-for-age z-score as predictors, and explained 94.5% variation in FFM with an RMSE of 402 g (precision error 4.5%).Conclusion: We present a BIA calibration equation for a group of stunted children with relatively low prediction error. This may help evaluate the efficacy of "nutritional supplementation in large-scale trials in the same population". J Nutr 20xx;xxx:xx.
AB - Background: BIA represents an important tool in body composition (BC) assessment, especially in low-income settings in which simple and affordable options are preferred. There is a particular need to measure BC in stunted children, in which cases population-specific BIA estimating equations are lacking.Objective: We calibrated an equation to estimate body composition from BIA using deuterium dilution (2H) as the criterion method in stunted children.Methods: We measured BC with 2H and performed BIA in stunted Ugandan children (n = 50). Multiple linear regression models were constructed to predict 2H-derived FFM from BIA-derived whole-body impedance and other relevant predictors. Model performance was expressed as adjusted R2 and RMSE. Prediction errors were also calculated.Results: Participants were aged 16-59 mo, at whom 46% were girls, and their median [IQR] height-for-age z-score (HAZ) was -2.58 [-2.92, -2.37] according to WHO growth standards. Impedance index (height2/impendance measured at 50 kHz) alone explained 89.2% variation in FFM and had an RMSE of 583 g (precision error 6.5%). The final model contained age, sex, impedance index and height-for-age z-score as predictors, and explained 94.5% variation in FFM with an RMSE of 402 g (precision error 4.5%).Conclusion: We present a BIA calibration equation for a group of stunted children with relatively low prediction error. This may help evaluate the efficacy of "nutritional supplementation in large-scale trials in the same population". J Nutr 20xx;xxx:xx.
KW - Faculty of Science
KW - Stunting
KW - Body composition
KW - Deuterium dilution
KW - Bioelectrical impedance analysis
KW - Fat-free mass
KW - Total body water
U2 - 10.1016/j.tjnut.2022.12.028
DO - 10.1016/j.tjnut.2022.12.028
M3 - Journal article
C2 - 36894235
VL - 153
SP - 426
EP - 434
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 2
ER -
ID: 330782366