During his short-lived but highly productive career, C. Wright Mills put forth a vision for how sociology should be done. Two central directives can be gleaned from this vision: to tackle macro social theory issues by doing large-scope research; to achieve scholastic independence by doing non-administrative research. One might ask if Mills is sending scholars on a mission impossible. Analysing these two concepts in terms of both their merits and applicability, the present article indeed identifies a conflict between them, highlighted by what emerges as Mills' own failure to realize this vision. After deeming these directives worthy goals, the article seeks to determine whether technological advances in the social sciences have the potential to allow both directives to be fulfilled at once. What is shown is that while the technology is ripe to enable autonomous big studies, its implementation by institutional and individual agents severely impedes the vision's realization.